A report by health charity the King's Fund showed that 4.2% of patients spent more than four hours in AE before being discharged or admitted from January to March, compared with 3.4% in the same period last year.
Its authors said the increase was a cause for concern and reflected growing pressures on the hospital sector.
The Government's national target that no more than 5% of patients face more than a four-hour wait in AE was met last year, the think-tank's quarterly monitoring report found.
But 48 NHS providers breached the threshold in the final quarter of last year compared with 18 in the second quarter.
John Appleby, chief economist at the King's Fund, said: "The number of organisations that are in breach of Government targets is really worrying.
"That's almost one in four hospitals in England. That is not good."
Health Secretary Andrew Lansley said the figures did not reflect the amount of time people spent waiting for treatment in AE.
He said: "This measure records the total time people spend in the department, including the time they are being treated. It does not just measure waiting.
"People are waiting on average only 49 minutes for their treatment to start. In addition, the NHS has continued to meet or exceed the target of 95% of patients spending a total time of four hours or less in AE."
The King's Fund said the rise in time spent in AE coincides with emerging evidence of increases in "trolley waits" as some hospitals struggle to find beds for patients.
Data obtained from 60 NHS finance directors as part of the study revealed that 40% of trusts did not meet their productivity targets in 2011/12.
The report said: "This will be a significant concern as last year was the first in a four-year spending squeeze, during which the NHS needs to find £20 billion in productivity improvements."
Just four of the finance chiefs questioned said their organisation was forecasting a deficit this year, backing up national figures that estimate a surplus of £1.5 billion across the NHS.
The study found the NHS was performing well against a number of other key indicators, including hospital treatment waiting times and superbug infections.
The proportion of inpatients waiting more than 18 weeks for treatment fell, while outpatient waits remained static, the report said. C difficile and MRSA infections dropped by 33% and 14% respectively.
Mr Appleby added: "Overall, the NHS continues to perform well, despite the spending squeeze. However, this masks growing pressures in hospitals and significant performance issues in some NHS organisations.
"Given the strength of the political commitment to keep waiting times low, the steep rise in AE waits will be a concern for the Government.
"The productivity challenge will only get harder, so evidence that large numbers of NHS organisations failed to meet their productivity targets last year does not bode well."
PA
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